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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Anti-DYNC1LI1 antibody (292-342 aa) (STJ192934)

  • 產(chǎn)品型號(hào)：STJ192934
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-DYNC1LI1 antibody (292-342 aa) (STJ192934)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cytoplasmic dynein 1 light intermediate chain 1 (292-342 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYNC1LI1
Gene ID: 51143
Uniprot ID: DC1L1_HUMAN
Immunogen Region: 292-342 aa
Specificity: DC1L1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein at the amino acid range 292-342
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC).
Protein Name Cytoplasmic Dynein 1 Light Intermediate Chain 1
Lic1
Dynein Light Chain A
Dlc-A
Dynein Light Intermediate Chain 1 - Cytosolic
Dlic-1
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2132295
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-3371497
Reactome: R-HSA-5663220
Reactome: R-HSA-6798695
Reactome: R-HSA-6807878
Reactome: R-HSA-6811436
Reactome: R-HSA-68877
Reactome: R-HSA-9609690
Reactome: R-HSA-9646399
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Chromosome
Centromere
Kinetochore
Cytoskeleton
Spindle Pole
Recycling Endosome Membrane
During Interphase
Localized In Vesicles Continuously Moving From Peripheral Sorting Endosomes In The Cell Towards The Pericentrosomal Endosomal Recycling Compartment (Erc)
Alternative Antibody Names Anti-Cytoplasmic Dynein 1 Light Intermediate Chain 1 antibody
Anti-Lic1 antibody
Anti-Dynein Light Chain A antibody
Anti-Dlc-A antibody
Anti-Dynein Light Intermediate Chain 1 - Cytosolic antibody
Anti-Dlic-1 antibody
Anti-DYNC1LI1 antibody
Anti-DNCLI1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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