產(chǎn)品詳情
簡(jiǎn)單介紹：
Anti-DCC antibody (1330-1380) {FITC} (STJ500740)
詳情介紹：
| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-DCC (1330-1380) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.50 μg/μl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | DCC |
| Gene ID: | 1630 |
| Uniprot ID: | DCC_HUMAN |
| Immunogen Region: | 1330-1380 |
| Immunogen: | Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein. |
| Tissue Specificity | Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. |
| Protein Name | Netrin Receptor Dcc Colorectal Cancer Suppressor Immunoglobulin Superfamily Dcc Subclass Member 1 Tumor Suppressor Protein Dcc |
| Database Links | Reactome: R-HSA-373752 Reactome: R-HSA-376172 Reactome: R-HSA-418885 Reactome: R-HSA-418886 Reactome: R-HSA-418889 Reactome: R-HSA-418890 Reactome: R-HSA-428542 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Netrin Receptor Dcc antibody Anti-Colorectal Cancer Suppressor antibody Anti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibody Anti-Tumor Suppressor Protein Dcc antibody Anti-DCC antibody Anti-IGDCC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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