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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse EGLN1 (Egl Nine Homolog 1) Sandwich ELISA Kit (STJE0008604)

  • 產(chǎn)品型號(hào)：STJE0008604
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Mouse EGLN1 (Egl Nine Homolog 1) Sandwich ELISA Kit (STJE0008604)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.108ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This EGLN1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Egln1
Gene ID: 112405
Uniprot ID: EGLN1_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in heart, brain liver, skeletal muscle and kidney. Low levels were detected in the lung. Constitutively expressed during differentiation of C2C12 skeletal myocytes.
Post Translational Modifications S-nitrosylation inhibits the enzyme activity up to 60% under aerobic conditions. Chelation of Fe(2+) has no effect on the S-nitrosylation. It is uncertain whether nitrosylation occurs on Cys-300 or Cys-303.
Function Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Protein Name Egl Nine Homolog 1
Hypoxia-Inducible Factor Prolyl Hydroxylase 2
Hif-Ph2
Hif-Prolyl Hydroxylase 2
Hph-2
Prolyl Hydroxylase Domain-Containing Protein 2
Phd2
Sm-20
Database Links Reactome: R-MMU-1234176
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic
Shuttles Between The Nucleus And Cytoplasm
Nuclear Export Requires Functional Xpo1
Alternative ELISA Names Egl Nine Homolog 1 ELISA kit
Hypoxia-Inducible Factor Prolyl Hydroxylase 2 ELISA kit
Hif-Ph2 ELISA kit
Hif-Prolyl Hydroxylase 2 ELISA kit
Hph-2 ELISA kit
Prolyl Hydroxylase Domain-Containing Protein 2 ELISA kit
Phd2 ELISA kit
Sm-20 ELISA kit
Egln1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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