產品詳情
簡單介紹：
Anti-FBLN5 antibody (199-448) (STJ112002)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-FBLN5 (199-448) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBLN5 |
| Gene ID: | 10516 |
| Uniprot ID: | FBLN5_HUMAN |
| Immunogen Region: | 199-448 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2). |
| Immunogen Sequence: | NEDGRSCQDVNECATENPCV QTCVNTYGSFICRCDPGYEL EEDGVHCSDMDECSFSEFLC QHECVNQPGTYFCSCPPGYI LLDDNRSCQDINECEHRNHT CNLQQTCYNLQGGFKCIDPI RCEEPYLRISDNRCMCPAEN PGCRDQPFTILYRDMDVVSG RSVPADIFQMQATTRYPGAY YIFQIKSGNEGREFYMRQTG PISATLVMTRPIKGPREIQL DLEMITVNTVINFRGSSVI |
| Tissue Specificity | Expressed in skin fibroblasts (at protein level). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes. |
| Post Translational Modifications | N-glycosylated. |
| Function | Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. |
| Protein Name | Fibulin-5 Fibl-5 Developmental Arteries And Neural Crest Egf-Like Protein Dance Urine P50 Protein Up50 |
| Database Links | Reactome: R-HSA-1566948 Reactome: R-HSA-2129379 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Co-Localizes With Eln In Elastic Fibers |
| Alternative Antibody Names | Anti-Fibulin-5 antibody Anti-Fibl-5 antibody Anti-Developmental Arteries And Neural Crest Egf-Like Protein antibody Anti-Dance antibody Anti-Urine P50 Protein antibody Anti-Up50 antibody Anti-FBLN5 antibody Anti-DANCE antibody Anti-UNQ184 antibody Anti-PRO210 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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