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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-FBLIM1 antibody (180-272) (STJ118295)

  • 產(chǎn)品型號(hào)：STJ118295
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-FBLIM1 antibody (180-272) (STJ118295)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FBLIM1 (180-272) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FBLIM1
Gene ID: 54751
Uniprot ID: FBLI1_HUMAN
Immunogen Region: 180-272
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-272 of human FBLIM1 (NP_060026.2).
Immunogen Sequence: TDICAFCHKTVSPRELAVEA MKRQYHAQCFTCRTCRRQLA GQSFYQKDGRPLCEPCYQDT LERCGKCGEVVRDHIIRALG QAFHPSCFTCVTC
Tissue Specificity Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
Function Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
Protein Name Filamin-Binding Lim Protein 1
Fblp-1
Migfilin
Mitogen-Inducible 2-Interacting Protein
Mig2-Interacting Protein
Database Links Reactome: R-HSA-446353
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Stress Fiber
Associated With Actin Stress Fiber At Cell-Ecm Focal Adhesion Sites
Isoform 1 And Isoform 3 Are Recruited And Localized At Actin Stress Fibers And Clustered At Cell-Emc Adhesion Sites Through Interaction With Fermt2
Isoform 2 Is Localized At Actin Stress Fibers
Alternative Antibody Names Anti-Filamin-Binding Lim Protein 1 antibody
Anti-Fblp-1 antibody
Anti-Migfilin antibody
Anti-Mitogen-Inducible 2-Interacting Protein antibody
Anti-Mig2-Interacting Protein antibody
Anti-FBLIM1 antibody
Anti-FBLP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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