產(chǎn)品詳情
簡單介紹：
Anti-FasLG antibody (154-170) (STJ23630)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-FasLG (154-170) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FASLG |
| Gene ID: | 356 |
| Uniprot ID: | TNFL6_HUMAN |
| Immunogen Region: | 154-170 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 154-170 of human FasLG (NP_000630.1). |
| Immunogen Sequence: | NSRSMPLEWEDTYGIVL |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. N-glycosylated. Glycosylation enhances apoptotic activity. Phosphorylated by FGR on tyrosine residues.this is required for ubiquitination and subsequent internalization. Monoubiquitinated. |
| Function | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 6 Apoptosis Antigen Ligand Aptl Cd95 Ligand Cd95-L Fas Antigen Ligand Fas Ligand Fasl Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form Receptor-Binding Fasl Ectodomain Soluble Fas Ligand Sfasl - Adam10-Processed Fasl Form Apl - Fasl Intracellular Domain Fasl Icd Sppl2a-Processed Fasl Form Spa |
| Database Links | Reactome: R-HSA-140534 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-6785807 Reactome: R-HSA-69416 Reactome: R-HSA-75157 Reactome: R-HSA-8862803 Reactome: R-HSA-9614657 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Cytoplasmic Vesicle Lumen Lysosome Lumen Is Internalized Into Multivesicular Bodies Of Secretory Lysosomes After Phosphorylation By Fgr And Monoubiquitination Colocalizes With The Sppl2a Protease At The Cell Membrane Tumor Necrosis Factor Ligand Superfamily Member 6 Soluble Form: Secreted May Be Released Into The Extracellular Fluid By Cleavage From The Cell Surface Fasl Intracellular Domain: Nucleus The Fasl Icd Cytoplasmic Form Is Translocated Into The Nucleus |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 6 antibody Anti-Apoptosis Antigen Ligand antibody Anti-Aptl antibody Anti-Cd95 Ligand antibody Anti-Cd95-L antibody Anti-Fas Antigen Ligand antibody Anti-Fas Ligand antibody Anti-Fasl antibody Anti-Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form antibody Anti-Receptor-Binding Fasl Ectodomain antibody Anti-Soluble Fas Ligand antibody Anti-Sfasl - Adam10-Processed Fasl Form antibody Anti-Apl - Fasl Intracellular Domain antibody Anti-Fasl Icd antibody Anti-Sppl2a-Processed Fasl Form antibody Anti-Spa antibody Anti-FASLG antibody Anti-APT1LG1 antibody Anti-CD95L antibody Anti-FASL antibody Anti-TNFSF6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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