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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse UGCG (UDP Glucose Ceramide Glucosyltransferase) Sandwich ELISA Kit (STJE0012920)

  • 產(chǎn)品型號：STJE0012920
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Mouse UGCG (UDP Glucose Ceramide Glucosyltransferase) Sandwich ELISA Kit (STJE0012920)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.28ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This UGCG Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ugcg
Gene ID: 22234
Uniprot ID: CEGT_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(11')-N-acylsphing-4-enine). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids. Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(11')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor.
Protein Name Ceramide Glucosyltransferase
Glct-1
Glucosylceramide Synthase
Gcs
Glycosylceramide Synthase
Udp-Glucose Ceramide Glucosyltransferase
Udp-Glucose -N-Acylsphingosine D-Glucosyltransferase
Database Links Reactome: R-MMU-1660662
Cellular Localisation Golgi Apparatus Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Ceramide Glucosyltransferase ELISA kit
Glct-1 ELISA kit
Glucosylceramide Synthase ELISA kit
Gcs ELISA kit
Glycosylceramide Synthase ELISA kit
Udp-Glucose Ceramide Glucosyltransferase ELISA kit
Udp-Glucose -N-Acylsphingosine D-Glucosyltransferase ELISA kit
Ugcg ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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