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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-FANCI antibody (1061-1328) (STJ23625)

  • 產(chǎn)品型號：STJ23625
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-FANCI antibody (1061-1328) (STJ23625)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FANCI (1061-1328) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FANCI
Gene ID: 55215
Uniprot ID: FANCI_HUMAN
Immunogen Region: 1061-1328
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1061-1328 of human FANCI (NP_001106849.1).
Immunogen Sequence: DQDVEVEKTNHFAIVNLRTA APTVCLLVLSQAEKVLEEVD WLITKLKGQVSQETLSEEAS SQATLPNQPVEKAIIMQLGT LLTFFHELVQTALPSGSCVD TLLKDLCKMYTTLTALVRYY LQVCQSSGGIPKNMEKLVKL SGSHLTPLCYSFISYVQNKS KSLNYTGEKKEKPAAVATAM ARVLRETKPIPNLIFAIEQY EKFLIHLSKKSKVNLMQHMK LSTSRDFKIKGNILDMVLR
Post Translational Modifications Monoubiquitinated by FANCL on Lys-523 during S phase and upon genotoxic stress. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the FANCA-FANCB-FANCC-FANCE-FANCF-FANCG-FANCM complex. Ubiquitination is required for binding to chromatin, DNA repair, and normal cell cycle progression. Monoubiquitination is stimulated by DNA-binding. Phosphorylated in response to DNA damage by ATM and/or ATR.
Function Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Protein Name Fanconi Anemia Group I Protein
Protein Faci
Database Links Reactome: R-HSA-6783310
Reactome: R-HSA-6796648
Cellular Localisation Nucleus
Cytoplasm
Observed In Spots Localized In Pairs On The Sister Chromatids Of Mitotic Chromosome Arms And Not Centromeres
One On Each Chromatids
These Foci Coincide With Common Fragile Sites
They Are Frequently Interlinked Through Blm-Associated Ultra-Fine Dna Bridges
Alternative Antibody Names Anti-Fanconi Anemia Group I Protein antibody
Anti-Protein Faci antibody
Anti-FANCI antibody
Anti-KIAA1794 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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