產(chǎn)品詳情
簡(jiǎn)單介紹:
Anti-FAN1 antibody (801-851 aa) (STJ196098)
詳情介紹:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Fanconi-associated nuclease 1 (801-851 aa) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | FAN1 |
Gene ID: | 22909 |
Uniprot ID: | FAN1_HUMAN |
Immunogen Region: | 801-851 aa |
Specificity: | This antibody detects endogenous levels of FAN1 at Human/Mouse |
Immunogen: | Synthesized peptide derived from the human FAN1 at the amino acid range 801-851 |
Function | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps. |
Protein Name | Fanconi-Associated Nuclease 1 Fancd2/Fanci-Associated Nuclease 1 Hfan1 Myotubularin-Related Protein 15 |
Database Links | Reactome: R-HSA-6783310 |
Cellular Localisation | Nucleus Localizes At Sites Of Dna Damage Following Recruitment By Monoubiquitinated Fancd2 Localizes To Stalled Replication Forks Via Its Ubz4-Type Zinc Finger |
Alternative Antibody Names | Anti-Fanconi-Associated Nuclease 1 antibody Anti-Fancd2/Fanci-Associated Nuclease 1 antibody Anti-Hfan1 antibody Anti-Myotubularin-Related Protein 15 antibody Anti-FAN1 antibody Anti-KIAA1018 antibody Anti-MTMR15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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