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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse TRPM4 (Transient Receptor Potential Cation Channel Subfamily M, Member 4) Sandwich ELISA Kit (STJE0012817)

  • 產(chǎn)品型號：STJE0012817
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Mouse TRPM4 (Transient Receptor Potential Cation Channel Subfamily M, Member 4) Sandwich ELISA Kit (STJE0012817)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.048ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This TRPM4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Trpm4
Gene ID: 68667
Uniprot ID: TRPM4_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Sino-atrial nodes (at protein level). Widely expressed.
Post Translational Modifications Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1.
Function Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells. Plays a role in keratinocyte differentiation.
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 4
Calcium-Activated Non-Selective Cation Channel 1
Long Transient Receptor Potential Channel 4
Ltrpc-4
Ltrpc4
Database Links Reactome: R-MMU-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Golgi Apparatus
Alternative ELISA Names Transient Receptor Potential Cation Channel Subfamily M Member 4 ELISA kit
Calcium-Activated Non-Selective Cation Channel 1 ELISA kit
Long Transient Receptor Potential Channel 4 ELISA kit
Ltrpc-4 ELISA kit
Ltrpc4 ELISA kit
Trpm4 ELISA kit
Ltrpc4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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