產品詳情
簡單介紹:
Mouse TOP2 (Topoisomerase II) Sandwich ELISA Kit (STJE0012735)
詳情介紹:
Applications: | ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.116ng/mL |
Detection Limit: | 0.312-20ng/mL |
Short Description: | This TOP2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 4.5 hrs |
Gene Symbol: | Top2a |
Gene ID: | 21973 |
Uniprot ID: | TOP2A_MOUSE |
Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Tissue Specificity | |
Post Translational Modifications | Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1105 by CSNK1D/CK1 promotes DNA cleavable complex formation. |
Function | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation. |
Protein Name | Dna Topoisomerase 2-Alpha Dna Topoisomerase Ii - Alpha Isozyme |
Database Links | Reactome: R-MMU-4615885 |
Cellular Localisation | Cytoplasm Nucleus Nucleoplasm Nucleolus |
Alternative ELISA Names | Dna Topoisomerase 2-Alpha ELISA kit Dna Topoisomerase Ii - Alpha Isozyme ELISA kit Top2a ELISA kit Top-2 ELISA kit Top2 ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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