產(chǎn)品詳情
簡單介紹：
Anti-F11R antibody (250-299) (STJ501518)
詳情介紹：
| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Bovine/Monkey/Mouse/Panda/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-F11R (250-299) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.52-0.63 μg/μl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | F11R |
| Gene ID: | 50848 |
| Uniprot ID: | JAM1_HUMAN |
| Immunogen Region: | 250-299 |
| Immunogen: | Synthetic peptide taken within amino acid region 250-299 on human Junctional Adhesion Molecule A protein. |
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Protein Name | Junctional Adhesion Molecule A Jam-A Junctional Adhesion Molecule 1 Jam-1 Platelet F11 Receptor Platelet Adhesion Molecule 1 Pam-1 Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2173791 Reactome: R-HSA-420029 |
| Cellular Localisation | Cell Junction Tight Junction Cell Membrane Single-Pass Type I Membrane Protein Localized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule A antibody Anti-Jam-A antibody Anti-Junctional Adhesion Molecule 1 antibody Anti-Jam-1 antibody Anti-Platelet F11 Receptor antibody Anti-Platelet Adhesion Molecule 1 antibody Anti-Pam-1 antibody Anti-Cd Antigen Cd321 antibody Anti-F11R antibody Anti-JAM1 antibody Anti-JCAM antibody Anti-UNQ264 antibody Anti-PRO301 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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