產(chǎn)品詳情
簡單介紹：
Anti-F10 antibody (41-300) (STJ117251)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-F10 (41-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | F10 |
| Gene ID: | 2159 |
| Uniprot ID: | FA10_HUMAN |
| Immunogen Region: | 41-300 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-300 of human F10 (NP_000495.1). |
| Immunogen Sequence: | ANSFLEEMKKGHLERECMEE TCSYEEAREVFEDSDKTNEF WNKYKDGDQCETSPCQNQGK CKDGLGEYTCTCLEGFEGKN CELFTRKLCSLDNGDCDQFC HEEQNSVVCSCARGYTLADN GKACIPTGPYPCGKQTLERR KRSVAQATSSSGEAPDSITW KPYDAADLDPTENPFDLLDF NQTQPERGDNNLTRIVGGQE CKDGECPWQALLINEENEGF CGGTILSEFYILTAAHCLY |
| Tissue Specificity | Plasma.synthesized in the liver. |
| Post Translational Modifications | The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Proteolytically cleaved and activated by cathepsin CTSG. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
| Protein Name | Coagulation Factor X Stuart Factor Stuart-Prower Factor Cleaved Into - Factor X Light Chain - Factor X Heavy Chain - Activated Factor Xa Heavy Chain |
| Database Links | Reactome: R-HSA-140834 Reactome: R-HSA-140837 Reactome: R-HSA-140875 Reactome: R-HSA-159740 Reactome: R-HSA-159763 Reactome: R-HSA-159782 Reactome: R-HSA-9672383 Reactome: R-HSA-9672396 Reactome: R-HSA-9673202 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor X antibody Anti-Stuart Factor antibody Anti-Stuart-Prower Factor Cleaved Into - Factor X Light Chain - Factor X Heavy Chain - Activated Factor Xa Heavy Chain antibody Anti-F10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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