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產品詳情

  • 產品名稱：Anti-EXTL3 antibody (STJ192125)

  • 產品型號：STJ192125
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-EXTL3 antibody (STJ192125)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Exostosin-like 3 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EXTL3
Gene ID: 2137
Uniprot ID: EXTL3_HUMAN
Specificity: EXTL3 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion. Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REGA through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REGA and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death.
Protein Name Exostosin-Like 3
Ext-Related Protein 1
Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase
Hereditary Multiple Exostoses Gene Isolog
Multiple Exostosis-Like Protein 3
Putative Tumor Suppressor Protein Extl3
Database Links Reactome: R-HSA-381038
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Golgi Apparatus
Cell Membrane
Nucleus
Interaction With Reg3a Induces Its Translocation To The Nucleus
Alternative Antibody Names Anti-Exostosin-Like 3 antibody
Anti-Ext-Related Protein 1 antibody
Anti-Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase antibody
Anti-Hereditary Multiple Exostoses Gene Isolog antibody
Anti-Multiple Exostosis-Like Protein 3 antibody
Anti-Putative Tumor Suppressor Protein Extl3 antibody
Anti-EXTL3 antibody
Anti-EXTL1L antibody
Anti-EXTR1 antibody
Anti-KIAA0519 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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