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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EXOSC5 antibody (1-235) (STJ118315)

  • 產(chǎn)品型號：STJ118315
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-EXOSC5 antibody (1-235) (STJ118315)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EXOSC5 (1-235) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EXOSC5
Gene ID: 56915
Uniprot ID: EXOS5_HUMAN
Immunogen Region: 1-235
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human EXOSC5 (NP_064543.3).
Immunogen Sequence: MEEETHTDAKIRAENGTGSS PRGPGCSLRHFACEQNLLSR PDGSASFLQGDTSVLAGVYG PAEVKVSKEIFNKATLEVIL RPKIGLPGVAEKSRERLIRN TCEAVVLGTLHPRTSITVVL QVVSDAGSLLACCLNAACMA LVDAGVPMRALFCGVACALD SDGTLVLDPTSKQEKEARAV LTFALDSVERKLLMSSTKGL YSDTELQQCLAAAQAASQHV FRFYRESLQRRYSKS
Tissue Specificity Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity.
Protein Name Exosome Complex Component Rrp46
Chronic Myelogenous Leukemia Tumor Antigen 28
Exosome Component 5
Ribosomal Rna-Processing Protein 46
P12b
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-429958
Reactome: R-HSA-450385
Reactome: R-HSA-450513
Reactome: R-HSA-450604
Reactome: R-HSA-6791226
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
Alternative Antibody Names Anti-Exosome Complex Component Rrp46 antibody
Anti-Chronic Myelogenous Leukemia Tumor Antigen 28 antibody
Anti-Exosome Component 5 antibody
Anti-Ribosomal Rna-Processing Protein 46 antibody
Anti-P12b antibody
Anti-EXOSC5 antibody
Anti-CML28 antibody
Anti-RRP46 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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