產(chǎn)品詳情
簡單介紹：
Anti-ETV4 antibody (40-484) (STJ118113)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ETV4 (40-484) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ETV4 |
| Gene ID: | 2118 |
| Uniprot ID: | ETV4_HUMAN |
| Immunogen Region: | 40-484 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-484 of human ETV4 (NP_001977.1). |
| Immunogen Sequence: | MDPGSLPPLDSEDLFQDLSH FQETWLAEAQVPDSDEQFVP DFHSENLAFHSPTTRIKKEP QSPRTDPALSCSRKPPLPYH HGEQCLYSSAYDPPRQIAIK SPAPGALGQSPLQPFPRAEQ RNFLRSSGTSQPHPGHGYLG EHSSVFQQPLDICHSFTSQG GGREPLPAPYQHQLSEPCPP YPQQSFKQEYHDPLYEQAGQ PAVDQGG |
| Tissue Specificity | Expressed in keratinocytes. |
| Post Translational Modifications | Sumoylated.enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2. |
| Function | Transcriptional activator. May play a role in keratinocyte differentiation. (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator.the core-binding sequence is 5'-ACGGAATGT-3'. |
| Protein Name | Ets Translocation Variant 4 Adenovirus E1a Enhancer-Binding Protein E1a-F Polyomavirus Enhancer Activator 3 Homolog Protein Pea3 |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Translocation Variant 4 antibody Anti-Adenovirus E1a Enhancer-Binding Protein antibody Anti-E1a-F antibody Anti-Polyomavirus Enhancer Activator 3 Homolog antibody Anti-Protein Pea3 antibody Anti-ETV4 antibody Anti-E1AF antibody Anti-PEA3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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