產(chǎn)品詳情
簡單介紹：
Anti-ETS1 antibody [8A8] (STJ98057)
詳情介紹：
| Host: | Mouse |
| Applications: | WB/IHC/IF/FC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Protein C-ets-1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 8A8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC 1:200-1:1000 IF 1:200-1:1000 FC 1:200-1:400 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ETS1 |
| Gene ID: | 2113 |
| Uniprot ID: | ETS1_HUMAN |
| Specificity: | ETS1 Monoclonal Antibody detects endogenous levels of ETS1 protein. |
| Immunogen: | Purified recombinant fragment of human ETS1 expressed in E. Coli. |
| Post Translational Modifications | Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2.which inhibits transcriptional activity. Ubiquitinated.which induces proteasomal degradation. Phosphorylation at Ser-251, Ser-282 and Ser-285 by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA: an increasing number of phosphoserines causes DNA-binding to become progressively weaker. |
| Function | Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Isoform Ets-1 p27: Acts as a dominant-negative for isoform c-ETS-1A. |
| Protein Name | Protein C-Ets-1 P54 |
| Database Links | Reactome: R-HSA-2559585 |
| Cellular Localisation | Nucleus Cytoplasm Delocalizes From Nucleus To Cytoplasm When Coexpressed With Isoform Ets-1 P27 |
| Alternative Antibody Names | Anti-Protein C-Ets-1 antibody Anti-P54 antibody Anti-ETS1 antibody Anti-EWSR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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