產(chǎn)品詳情
簡單介紹：
Anti-ETF1 antibody (278-437) (STJ27716)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ETF1 (278-437) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:200-1:2000 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ETF1 |
| Gene ID: | 2107 |
| Uniprot ID: | ERF1_HUMAN |
| Immunogen Region: | 278-437 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 278-437 of human ETF1 (NP_004721.1). |
| Immunogen Sequence: | VKFIQEKKLIGRYFDEISQD TGKYCFGVEDTLKALEMGAV EILIVYENLDIMRYVLHCQG TEEEKILYLTPEQEKDKSHF TDKETGQEHELIESMPLLEW FANNYKKFGATLEIVTDKSQ EGSQFVKGFGGIGGILRYRV DFQGMEYQGGDDEFFDLDDY |
| Post Translational Modifications | Methylated at Gln-185 by N6AMT1. Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency. Ubiquitinated via 'Lys-6'-linked polyubiquitin chains by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes. |
| Function | Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. |
| Protein Name | Eukaryotic Peptide Chain Release Factor Subunit 1 Eukaryotic Release Factor 1 Erf1 Protein Cl1 Tb3-1 |
| Database Links | Reactome: R-HSA-72764 Reactome: R-HSA-9010553 Reactome: R-HSA-975956 Reactome: R-HSA-975957 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Peptide Chain Release Factor Subunit 1 antibody Anti-Eukaryotic Release Factor 1 antibody Anti-Erf1 antibody Anti-Protein Cl1 antibody Anti-Tb3-1 antibody Anti-ETF1 antibody Anti-ERF1 antibody Anti-RF1 antibody Anti-SUP45L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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