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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse Smad2 (Mothers Against Decapentaplegic Homolog 2) Sandwich ELISA Kit Ready-To-Use (STJE0018616)

  • 產(chǎn)品型號(hào)：STJE0018616
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Mouse Smad2 (Mothers Against Decapentaplegic Homolog 2) Sandwich ELISA Kit Ready-To-Use (STJE0018616)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 24.6pg/mL
Detection Limit: 62.5-4000pg/mL
Short Description: This Smad2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Smad2
Gene ID: 17126
Uniprot ID: SMAD2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications In response to TGF-beta, phosphorylated on the C-terminal SXS motif by TGF-beta and activin type 1 receptor kinases, phosphorylation declines progressively in a KMT5A-dependent manner. Phosphorylation in this motif is required for interaction with a number of proteins including SMURF2, SNON and SMAD4 in response to TGF-beta. Dephosphorylated in this motif by PPM1A leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of the TGF-beta signaling. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation.which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1. In response to TGF-beta, ubiquitinated by NEDD4L.which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover. Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity.
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Protein Name Mothers Against Decapentaplegic Homolog 2
Mad Homolog 2
Mothers Against Dpp Homolog 2
Mad-Related Protein 2
Mmad2
Smad Family Member 2
Smad 2
Smad2
Database Links Reactome: R-MMU-1181150
Reactome: -MMU-1502540
Reactome: -MMU-2173788
Reactome: -MMU-2173789
Reactome: -MMU-2173795
Reactome: -MMU-2173796
Reactome: -MMU-5689880
Reactome: -MMU-9617828
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic And Nuclear In The Absence Of Tgf-Beta
On Tgf-Beta Stimulation
Migrates To The Nucleus When Complexed With Smad4 Or With Ipo7
On Dephosphorylation By Phosphatase Ppm1a
Released From The Smad2/Smad4 Complex
And Exported Out Of The Nucleus By Interaction With Ranbp1
Localized Mainly To The Nucleus In The Early Stages Of Embryo Development With Expression Becoming Evident In The Cytoplasm At The Blastocyst And Epiblast Stages
Alternative ELISA Names Mothers Against Decapentaplegic Homolog 2 ELISA kit
Mad Homolog 2 ELISA kit
Mothers Against Dpp Homolog 2 ELISA kit
Mad-Related Protein 2 ELISA kit
Mmad2 ELISA kit
Smad Family Member 2 ELISA kit
Smad 2 ELISA kit
Smad2 ELISA kit
Smad2 ELISA kit
Madh2 ELISA kit
Madr2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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