產(chǎn)品詳情
簡單介紹：
Anti-ESPL1 antibody (1220-1500) (STJ117561)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ESPL1 (1220-1500) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:200-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESPL1 |
| Gene ID: | 9700 |
| Uniprot ID: | ESPL1_HUMAN |
| Immunogen Region: | 1220-1500 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1220-1500 of human ESPL1 (NP_036423.4). |
| Immunogen Sequence: | DEILAQAYTLLALEGLNQPS NESLQKVLQSGLKFVAARIP HLEPWRASLLLIWALTKLGG LSCCTTQLFASSWGWQPPLI KSVPGSEPSKTQGQKRSGRG RQKLASAPLRLNNTSQKGLE GRGLPCTPKPPDRIRQAGPH VPFTVFEEVCPTESKPEVPQ APRVQQRVQTRLKVNFSDDS DLEDPVSAEAWLAEEPKRRG TASRGRGRARKGLSLKTDAV VAPGSAPGNPGLNGRSRRA |
| Post Translational Modifications | Autocleaves. This function, which is not essential for its protease activity, is unknown. Phosphorylated by CDK1. There are 8 Ser/Thr phosphorylation sites. Among them, Ser-1126 phosphorylation is the major site, which conducts to the enzyme inactivation. |
| Function | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
| Protein Name | Separin Caspase-Like Protein Espl1 Extra Spindle Poles-Like 1 Protein Separase |
| Database Links | Reactome: R-HSA-2467813 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Separin antibody Anti-Caspase-Like Protein Espl1 antibody Anti-Extra Spindle Poles-Like 1 Protein antibody Anti-Separase antibody Anti-ESPL1 antibody Anti-ESP1 antibody Anti-KIAA0165 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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