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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit Ready-To-Use (STJE0018562)

  • 產(chǎn)品型號：STJE0018562
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit Ready-To-Use (STJE0018562)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SIRT3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Sirt3
Gene ID: 64384
Uniprot ID: SIR3_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Strongly expressed in liver and kidney. Expressed in skeletal muscles (at protein level). Weakly expressed in lung.
Post Translational Modifications
Function NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation. Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance.
Protein Name Nad-Dependent Protein Deacetylase Sirtuin-3
Regulatory Protein Sir2 Homolog 3
Sir2-Like Protein 3
Msir2l3
Database Links Reactome: R-MMU-2151201
Reactome: -MMU-9617629
Cellular Localisation Isoform L: Mitochondrion Matrix
Isoform S: Cytoplasm
Alternative ELISA Names Nad-Dependent Protein Deacetylase Sirtuin-3 ELISA kit
Regulatory Protein Sir2 Homolog 3 ELISA kit
Sir2-Like Protein 3 ELISA kit
Msir2l3 ELISA kit
Sirt3 ELISA kit
Sir2l3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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