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產品詳情

  • 產品名稱：Mouse SGLT1 (Sodium/Glucose Cotransporter 1) Sandwich ELISA Kit Ready-To-Use (STJE0018524)

  • 產品型號：STJE0018524
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Mouse SGLT1 (Sodium/Glucose Cotransporter 1) Sandwich ELISA Kit Ready-To-Use (STJE0018524)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SGLT1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Slc5a1
Gene ID: 20537
Uniprot ID: SC5A1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in enterocytes and enteroendocrine cells of small intestine (at protein level). Expressed in S3 segments of renal proximal tubules (at protein level). Expressed in endometrial glandular and epithelial cells (at protein level).
Post Translational Modifications N-glycosylation is not necessary for the cotransporter function.
Function Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
Protein Name Sodium/Glucose Cotransporter 1
Na(+/Glucose Cotransporter 1
High Affinity Sodium-Glucose Cotransporter
Solute Carrier Family 5 Member 1
Database Links Reactome: R-MMU-189200
Reactome: -MMU-8981373
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Sodium/Glucose Cotransporter 1 ELISA kit
Na(+/Glucose Cotransporter 1 ELISA kit
High Affinity Sodium-Glucose Cotransporter ELISA kit
Solute Carrier Family 5 Member 1 ELISA kit
Slc5a1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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