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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ERLIN2 antibody (25-152) (STJ110612)

  • 產(chǎn)品型號(hào)：STJ110612
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ERLIN2 antibody (25-152) (STJ110612)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ERLIN2 (25-152) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERLIN2
Gene ID: 11160
Uniprot ID: ERLN2_HUMAN
Immunogen Region: 25-152
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-152 of human ERLIN2 (NP_001003790.1).
Immunogen Sequence: KIEEGHIGVYYRGGALLTST SGPGFHLMLPFITSYKSVQT TLQTDEVKNVPCGTSGGVMI YFDRIEVVNFLVPNAVYDIV KNYTADYDKALIFNKIHHEL NQFCSVHTLQEVYIELFGLE NDFSQESS
Tissue Specificity Ubiquitous.
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
Protein Name Erlin-2
Endoplasmic Reticulum Lipid Raft-Associated Protein 2
Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2
Spfh Domain-Containing Protein 2
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5655302
Reactome: R-HSA-5678895
Reactome: R-HSA-8853336
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Erlin-2 antibody
Anti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibody
Anti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibody
Anti-Spfh Domain-Containing Protein 2 antibody
Anti-ERLIN2 antibody
Anti-C8orf2 antibody
Anti-SPFH2 antibody
Anti-UNQ2441 antibody
Anti-PRO5003 antibody
Anti-PRO9924 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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