產(chǎn)品詳情
簡單介紹：
Anti-ERLIN1 antibody (259-348) (STJ117043)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ERLIN1 (259-348) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 IP 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERLIN1 |
| Gene ID: | 10613 |
| Uniprot ID: | ERLN1_HUMAN |
| Immunogen Region: | 259-348 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 259-348 of human ERLIN1 (NP_006450.2). |
| Immunogen Sequence: | KADAEYYAAHKYATSNKHKL TPEYLELKKYQAIASNSKIY FGSNIPNMFVDSSCALKYSD IRTGRESSLPSKEALEPSGE NVIQNKESTG |
| Tissue Specificity | Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. |
| Protein Name | Erlin-1 Endoplasmic Reticulum Lipid Raft-Associated Protein 1 Protein Ke04 Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 Spfh Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-382556 Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-1 antibody Anti-Endoplasmic Reticulum Lipid Raft-Associated Protein 1 antibody Anti-Protein Ke04 antibody Anti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 antibody Anti-Spfh Domain-Containing Protein 1 antibody Anti-ERLIN1 antibody Anti-C10orf69 antibody Anti-KE04 antibody Anti-KEO4 antibody Anti-SPFH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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