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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-CD74 antibody (56-215) (STJ11105354)

  • 產(chǎn)品型號(hào)：STJ11105354
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-CD74 antibody (56-215) (STJ11105354)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD74 (56-215) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Cd74
Gene ID: 16149
Uniprot ID: HG2A_MOUSE
Immunogen Region: 56-215
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 56-215 of mouse CD74 (NP_034675.1).
Immunogen Sequence: QQQGRLDKLTITSQNLQLES LRMKLPKSAKPVSQMRMATP LLMRPMSMDNMLLGPVKNVT KYGNMTQDHVMHLLTRSGPL EYPQLKGTFPENLKHLKNSM DGVNWKIFESWMKQWLLFEM SKNSLEEKKPTEAPPKEPLD MEDLSSGLGVTRQELGQVTL
Tissue Specificity Isoform Long: Expressed in thymus and lymph noodes. Expressed by antigen-presenting cells (APCs). Isoform Short: Expressed in thymus and lymph noodes.
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. Isoform Long: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.
Protein Name H-2 Class Ii Histocompatibility Antigen Gamma Chain
Ia Antigen-Associated Invariant Chain
Ii
Ii Chain
Mhc Class Ii-Associated Invariant Chain
Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide
Clip
Database Links Reactome: R-MMU-202733
Reactome: -MMU-2132295
Cellular Localisation Isoform Long: Late Endosome
Lysosome
Cell Membrane
Single-Pass Type Ii Membrane Protein
Endoplasmic Reticulum Membrane
Golgi Apparatus
Trans-Golgi Network
Endosome
Secreted
Transits Through A Number Of Intracellular Compartments In The Endocytic Pathway
It Can Either Undergo Proteolysis Or Reach The Cell Membrane
Alternative Antibody Names Anti-H-2 Class Ii Histocompatibility Antigen Gamma Chain antibody
Anti-Ia Antigen-Associated Invariant Chain antibody
Anti-Ii antibody
Anti-Ii Chain antibody
Anti-Mhc Class Ii-Associated Invariant Chain antibody
Anti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibody
Anti-Clip antibody
Anti-Cd74 antibody
Anti-Ii antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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