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產品名稱：Anti-ERCC2 antibody (220-300 aa) (STJ190429)
產品型號：STJ190429
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-ERCC2 antibody (220-300 aa) (STJ190429)

詳情介紹：

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-General transcription and DNA repair factor IIH helicase subunit XPD (220-300 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ERCC2
Gene ID:	2068
Uniprot ID:	ERCC2_HUMAN
Immunogen Region:	220-300 aa
Specificity:	ERCC2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from the human protein at the amino acid range 220-300

Function	ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Protein Name	General Transcription And Dna Repair Factor Iih Helicase Subunit Xpd Tfiih Subunit Xpd Basic Transcription Factor 2 80 Kda Subunit Btf2 P80 Cxpd Dna Excision Repair Protein Ercc-2 Dna Repair Protein Complementing Xp-D Cells Tfiih Basal Transcription Factor Complex 80 Kda Subunit Tfiih 80 Kda Subunit Tfiih P80 Xeroderma Pigmentosum Group D-Complementing Protein
Database Links	Reactome: R-HSA-112382 Reactome: R-HSA-113418 Reactome: R-HSA-167152 Reactome: R-HSA-167158 Reactome: R-HSA-167160 Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-167200 Reactome: R-HSA-167246 Reactome: R-HSA-2564830 Reactome: R-HSA-427413 Reactome: R-HSA-5696395 Reactome: R-HSA-5696400 Reactome: R-HSA-674695 Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-6796648 Reactome: R-HSA-72086 Reactome: R-HSA-73762 Reactome: R-HSA-73772 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-73863 Reactome: R-HSA-75953 Reactome: R-HSA-75955 Reactome: R-HSA-76042 Reactome: R-HSA-77075
Cellular Localisation	Nucleus Cytoplasm Cytoskeleton Spindle
Alternative Antibody Names	Anti-General Transcription And Dna Repair Factor Iih Helicase Subunit Xpd antibody Anti-Tfiih Subunit Xpd antibody Anti-Basic Transcription Factor 2 80 Kda Subunit antibody Anti-Btf2 P80 antibody Anti-Cxpd antibody Anti-Dna Excision Repair Protein Ercc-2 antibody Anti-Dna Repair Protein Complementing Xp-D Cells antibody Anti-Tfiih Basal Transcription Factor Complex 80 Kda Subunit antibody Anti-Tfiih 80 Kda Subunit antibody Anti-Tfiih P80 antibody Anti-Xeroderma Pigmentosum Group D-Complementing Protein antibody Anti-ERCC2 antibody Anti-XPD antibody Anti-XPDC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ERCC2 antibody (220-300 aa) (STJ190429)