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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse RSPO1 (R-Spondin 1) Sandwich ELISA Kit (STJE0011949)

  • 產(chǎn)品型號(hào)：STJE0011949
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Mouse RSPO1 (R-Spondin 1) Sandwich ELISA Kit (STJE0011949)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.8pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This RSPO1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Rspo1
Gene ID: 192199
Uniprot ID: RSPO1_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in the dorsal part of the neural tube on 10 and 12 dpc, especially in the boundary region between roof plate and neuroepithelium. This expression is enhanced in the rostral part. Also expressed in other tissues such as truncal region neighboring forelimbs and mesenchymal tissues around the nasal cavity.
Post Translational Modifications
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1.
Protein Name R-Spondin-1
Cysteine-Rich And Single Thrombospondin Domain-Containing Protein 3
Cristin-3
Mcristin-3
Roof Plate-Specific Spondin-1
Database Links Reactome: R-MMU-4641263
Cellular Localisation Secreted
Nucleus
Seems To Mainly Localize To Nucleoli
Alternative ELISA Names R-Spondin-1 ELISA kit
Cysteine-Rich And Single Thrombospondin Domain-Containing Protein 3 ELISA kit
Cristin-3 ELISA kit
Mcristin-3 ELISA kit
Roof Plate-Specific Spondin-1 ELISA kit
Rspo1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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