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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EPRS1 antibody (STJ193060)

  • 產(chǎn)品型號(hào)：STJ193060
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-EPRS1 antibody (STJ193060)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Bifunctional glutamate/proline--tRNA ligase is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPRS1
Gene ID: 2058
Uniprot ID: SYEP_HUMAN
Specificity: SYEP Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition. Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan.
Protein Name Bifunctional Glutamate/Proline--Trna Ligase
Bifunctional Aminoacyl-Trna Synthetase
Cell Proliferation-Inducing Gene 32 Protein
Glutamatyl-Prolyl-Trna Synthetase Includes - Glutamate--Trna Ligase
Glutamyl-Trna Synthetase
Glurs - Proline--Trna Ligase
Prolyl-Trna Synthetase
Database Links Reactome: R-HSA-2408522
Reactome: R-HSA-379716
Reactome: R-HSA-6782315
Cellular Localisation Cytoplasm
Cytosol
Membrane
Peripheral Membrane Protein
Translocates From Cytosol To Membranes Upon Phosphorylation At Ser-999
Alternative Antibody Names Anti-Bifunctional Glutamate/Proline--Trna Ligase antibody
Anti-Bifunctional Aminoacyl-Trna Synthetase antibody
Anti-Cell Proliferation-Inducing Gene 32 Protein antibody
Anti-Glutamatyl-Prolyl-Trna Synthetase Includes - Glutamate--Trna Ligase antibody
Anti-Glutamyl-Trna Synthetase antibody
Anti-Glurs - Proline--Trna Ligase antibody
Anti-Prolyl-Trna Synthetase antibody
Anti-EPRS1 antibody
Anti-EPRS antibody
Anti-GLNS antibody
Anti-PARS antibody
Anti-QARS antibody
Anti-QPRS antibody
Anti-PIG32 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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