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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EPOR antibody (274-508) (STJ23553)

  • 產(chǎn)品型號：STJ23553
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-EPOR antibody (274-508) (STJ23553)
詳情介紹：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EPOR (274-508) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPOR
Gene ID: 2057
Uniprot ID: EPOR_HUMAN
Immunogen Region: 274-508
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 274-508 of human EPOR (NP_000112.1).
Immunogen Sequence: HRRALKQKIWPGIPSPESEF EGLFTTHKGNFQLWLYQNDG CLWWSPCTPFTEDPPASLEV LSERCWGTMQAVEPGTDDEG PLLEPVGSEHAQDTYLVLDK WLLPRNPPSEDLPGPGGSVD IVAMDEGSEASSCSSALASK PSPEGASAASFEYTILDPSS QLLRPWTLCPELPPTPPHLK YLYLVVSDSGISTDYSSGDS QGAQGGLSDGPYSNPYENSL IPAAEPLPPSYVACS
Tissue Specificity Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.
Post Translational Modifications On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site. Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation. Ubiquitinated by NOSIP.appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.
Function Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
Protein Name Erythropoietin Receptor
Epo-R
Database Links Reactome: R-HSA-9006335
Reactome: R-HSA-9027276
Reactome: R-HSA-9027277
Reactome: R-HSA-9027283
Reactome: R-HSA-9027284
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Epor-S: Secreted
Secreted And Located To The Cell Surface
Alternative Antibody Names Anti-Erythropoietin Receptor antibody
Anti-Epo-R antibody
Anti-EPOR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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