產(chǎn)品詳情
簡單介紹：
Mouse PXR (Pregnane X Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018169)
詳情介紹：
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.049ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This PXR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Nr1i2 |
| Gene ID: | 18171 |
| Uniprot ID: | NR1I2_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN). |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2 Orphan Nuclear Receptor Pxr Pregnane X Receptor |
| Database Links | Reactome: R-MMU-383280 Reactome: -MMU-4090294 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Nuclear Receptor Subfamily 1 Group I Member 2 ELISA kit Orphan Nuclear Receptor Pxr ELISA kit Pregnane X Receptor ELISA kit Nr1i2 ELISA kit Pxr ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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