產(chǎn)品詳情
簡單介紹：
Mouse PTPN11 (Protein Tyrosine Phosphatase, Non Receptor Type 11) Sandwich ELISA Kit (STJE0011765)
詳情介紹：
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.31ng/mL |
| Detection Limit: | 0.781-50ng/mL |
| Short Description: | This PTPN11 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Ptpn11 |
| Gene ID: | 19247 |
| Uniprot ID: | PTN11_MOUSE |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Highly expressed in brain, heart and kidney. |
| Post Translational Modifications | Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation.which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated by activated PDGFRB. Phosphorylated upon activation of the receptor-type kinase PDGFRA. |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 11 Protein-Tyrosine Phosphatase Syp Sh-Ptp2 Shp-2 Shp2 |
| Database Links | Reactome: R-MMU-1059683 Reactome: -MMU-109704 Reactome: -MMU-110056 Reactome: -MMU-112411 Reactome: -MMU-114604 Reactome: -MMU-1257604 Reactome: -MMU-1295596 Reactome: -MMU-1433557 Reactome: -MMU-180292 Reactome: -MMU-186763 Reactome: -MMU-210990 Reactome: -MMU-210993 Reactome: -MMU-388841 Reactome: -MMU-389513 Reactome: -MMU-389948 Reactome: -MMU-432142 Reactome: -MMU-512988 Reactome: -MMU-5654689 Reactome: -MMU-5654693 Reactome: -MMU-5654695 Reactome: -MMU-5654700 Reactome: -MMU-5654706 Reactome: -MMU-5654710 Reactome: -MMU-5654712 Reactome: -MMU-5654720 Reactome: -MMU-5654726 Reactome: -MMU-5654727 Reactome: -MMU-5654732 Reactome: -MMU-5654733 Reactome: -MMU-6811558 Reactome: -MMU-8853659 Reactome: -MMU-8854691 Reactome: -MMU-8865999 Reactome: -MMU-8934593 Reactome: -MMU-912694 Reactome: -MMU-936964 Reactome: -MMU-9674555 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Tyrosine-Protein Phosphatase Non-Receptor Type 11 ELISA kit Protein-Tyrosine Phosphatase Syp ELISA kit Sh-Ptp2 ELISA kit Shp-2 ELISA kit Shp2 ELISA kit Ptpn11 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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