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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EPHA8 antibody (28-300) (STJ112251)

  • 產(chǎn)品型號(hào)：STJ112251
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-EPHA8 antibody (28-300) (STJ112251)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EPHA8 (28-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHA8
Gene ID: 2046
Uniprot ID: EPHA8_HUMAN
Immunogen Region: 28-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 28-300 of human EPHA8 (NP_001006944.1).
Immunogen Sequence: ARGEVNLLDTSTIHGDWGWL TYPAHGWDSINEVDESFQPI HTYQVCNVMSPNQNNWLRTS WVPRDGARRVYAEIKFTLRD CNSMPGVLGTCKETFNLYYL ESDRDLGASTQESQFLKIDT IAADESFTGADLGVRRLKLN TEVRSVGPLSKRGFYLAFQD IGACLAILSLRIYYKKCPAM VRNLAAFSEAVTGADSSSLV EVRGQCVRHSEERDTPKMYC SAEGEWLVPIGKCVCSAGY
Post Translational Modifications Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine kinase activity. Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
Protein Name Ephrin Type-A Receptor 8
Eph- And Elk-Related Kinase
Eph-Like Kinase 3
Ek3
Hek3
Tyrosine-Protein Kinase Receptor Eek
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Early Endosome Membrane
Undergoes Clathrin-Mediated Endocytosis Upon Efna5-Binding And Is Targeted To Early Endosomes
Alternative Antibody Names Anti-Ephrin Type-A Receptor 8 antibody
Anti-Eph- And Elk-Related Kinase antibody
Anti-Eph-Like Kinase 3 antibody
Anti-Ek3 antibody
Anti-Hek3 antibody
Anti-Tyrosine-Protein Kinase Receptor Eek antibody
Anti-EPHA8 antibody
Anti-EEK antibody
Anti-HEK3 antibody
Anti-KIAA1459 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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