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產(chǎn)品名稱(chēng)：Mouse PRNP (Prion Protein) Sandwich ELISA Kit Ready-To-Use (STJE0018061)
產(chǎn)品型號(hào)：STJE0018061
產(chǎn)品廠商：ST john's laboratory
產(chǎn)品文檔：

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Mouse PRNP (Prion Protein) Sandwich ELISA Kit Ready-To-Use (STJE0018061)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.061ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This PRNP Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Prnp
Gene ID:	19122
Uniprot ID:	PRIO_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Highly expressed in the brain, lung, kidney and heart. Expressed at low levels in the liver and spleen.
Post Translational Modifications	N-glycosylated.
Function	Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Protein Name	Major Prion Protein Prp Prp27-30 Prp33-35c Cd Antigen Cd230
Database Links	Reactome: R-MMU-9609523
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Golgi Apparatus Targeted To Lipid Rafts Via Association With The Heparan Sulfate Chains Of Gpc1 Colocates In The Presence Of Cu(2+) To Vesicles In Para- And Perinuclear Regions Where Both Proteins Undergo Internalization Heparin Displaces Prnp From Lipid Rafts And Promotes Endocytosis
Alternative ELISA Names	Major Prion Protein ELISA kit Prp ELISA kit Prp27-30 ELISA kit Prp33-35c ELISA kit Cd Antigen Cd230 ELISA kit Prnp ELISA kit Prn-p ELISA kit Prp ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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