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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Mouse PRKG1 (Protein Kinase, cGMP Dependent Type I) Sandwich ELISA Kit Ready-To-Use (STJE0018051)

  • 產(chǎn)品型號(hào)：STJE0018051
  • 產(chǎn)品廠(chǎng)商：ST john's laboratory
  • 產(chǎn)品文檔：
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Mouse PRKG1 (Protein Kinase, cGMP Dependent Type I) Sandwich ELISA Kit Ready-To-Use (STJE0018051)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PRKG1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Prkg1
Gene ID: 19091
Uniprot ID: KGP1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Detected in cerebellum, hippocampus, dorsomedial hypothalamus, medulla, subcommissural organ, cerebral cortex, amygdala, habenulae, various hypothalamic regions, olfactory bulb, pituitary gland, and retina. Isoform alpha is prominent in the cerebellum and medulla, whereas isoform Beta is predominant in the cortex, hippocampus, hypothalamus, and olfactory bulb.
Post Translational Modifications Autophosphorylation increases kinase activity. 65 kDa monomer is produced by proteolytic cleavage.
Function Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation.decreasing contraction.controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle.
Protein Name Cgmp-Dependent Protein Kinase 1
Cgk 1
Cgk1
Cgmp-Dependent Protein Kinase I
Cgki
Database Links Reactome: R-MMU-392517
Reactome: -MMU-418457
Cellular Localisation Cytoplasm
Colocalized With Trpc7 In The Plasma Membrane
Alternative ELISA Names Cgmp-Dependent Protein Kinase 1 ELISA kit
Cgk 1 ELISA kit
Cgk1 ELISA kit
Cgmp-Dependent Protein Kinase I ELISA kit
Cgki ELISA kit
Prkg1 ELISA kit
Prkg1b ELISA kit
Prkgr1a ELISA kit
Prkgr1b ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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