產(chǎn)品詳情
簡單介紹：
Anti-EPHA1 antibody (1-230) (STJ29467)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EPHA1 (1-230) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPHA1 |
| Gene ID: | 2041 |
| Uniprot ID: | EPHA1_HUMAN |
| Immunogen Region: | 1-230 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EPHA1 (NP_005223.4). |
| Immunogen Sequence: | MERRWPLGLGLVLLLCAPLP PGARAKEVTLMDTSKAQGEL GWLLDPPKDGWSEQQQILNG TPLYMYQDCPMQGRRDTDHW LRSNWIYRGEEASRVHVELQ FTVRDCKSFPGGAGPLGCKE TFNLLYMESDQDVGIQLRRP LFQKVTTVAADQSFTIRDLV SGSVKLNVERCSLGRLTRRG LYLAFHNPGACVALVSVRVF YQRCPETLNGLAQFPDTLPG PAGLVEVAGT |
| Tissue Specificity | Overexpressed in several carcinomas. |
| Post Translational Modifications | Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. Ubiquitinated. |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
| Protein Name | Ephrin Type-A Receptor 1 Hepha1 Eph Tyrosine Kinase Eph Tyrosine Kinase 1 Erythropoietin-Producing Hepatoma Receptor Tyrosine-Protein Kinase Receptor Eph |
| Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-2892247 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Ephrin Type-A Receptor 1 antibody Anti-Hepha1 antibody Anti-Eph Tyrosine Kinase antibody Anti-Eph Tyrosine Kinase 1 antibody Anti-Erythropoietin-Producing Hepatoma Receptor antibody Anti-Tyrosine-Protein Kinase Receptor Eph antibody Anti-EPHA1 antibody Anti-EPH antibody Anti-EPHT antibody Anti-EPHT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關(guān)信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細胞培養(yǎng)玄學(xué)-MRC-5細胞 2025-01-07
- Ocean NanoTech定制的詳細步驟 2021-10-31
- click chemistry tools數(shù)據(jù)結(jié)果比... 2021-10-31
- LaysanBio代理商相關(guān)文獻資料2020 2021-10-31
- Abbiotec代理的產(chǎn)品得到重復(fù)驗證2020 2021-10-31
- zyagen Laboratories代理的產(chǎn)品得到... 2021-06-20
- Toxin Technologies代理商相關(guān)文獻資... 2021-03-14
- 熱烈祝賀玉博生物正式代理biocolor公司試劑產(chǎn)品... 2021-03-14
- 熱烈祝賀玉博生物正式代理cytognos公司試劑產(chǎn)品... 2021-03-14
- Gelest代理的產(chǎn)品得到重復(fù)驗證2020 2021-03-14
