產(chǎn)品詳情
簡單介紹：
Anti-EPB41 antibody (210-500) (STJ114308)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EPB41 (210-500) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPB41 |
| Gene ID: | 2035 |
| Uniprot ID: | EPB41_HUMAN |
| Immunogen Region: | 210-500 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-500 of human EPB41 (NP_001159478.1). |
| Immunogen Sequence: | MHCKVSLLDDTVYECVVEKH AKGQDLLKRVCEHLNLLEED YFGLAIWDNATSKTWLDSAK EIKKQVRGVPWNFTFNVKFY PPDPAQLTEDITRYYLCLQL RQDIVAGRLPCSFATLALLG SYTIQSELGDYDPELHGVDY VSDFKLAPNQTKELEEKVME LHKSYRSMTPAQADLEFLEN AKKLSMYGVDLHKAKDLEGV DIILGVCSSGLLVYKDKLRI NRFPWPKVLKISYKRSSFF |
| Post Translational Modifications | Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions. Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex. O-glycosylated.contains N-acetylglucosamine side chains in the C-terminal domain. |
| Function | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. |
| Protein Name | Protein 4.1 P4.1 4.1r Band 4.1 Epb4.1 Erythrocyte Membrane Protein Band 4.1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Cortex Nucleus |
| Alternative Antibody Names | Anti-Protein 4.1 antibody Anti-P4.1 antibody Anti-4.1r antibody Anti-Band 4.1 antibody Anti-Epb4.1 antibody Anti-Erythrocyte Membrane Protein Band 4.1 antibody Anti-EPB41 antibody Anti-E41P antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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