產(chǎn)品詳情
簡單介紹：
Anti-EP400 antibody (2057-2107 aa) (STJ196621)
詳情介紹：
| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-E1A-binding protein p400 (2057-2107 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EP400 |
| Gene ID: | 57634 |
| Uniprot ID: | EP400_HUMAN |
| Immunogen Region: | 2057-2107 aa |
| Specificity: | This antibody detects endogenous levels of EP400 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human EP400 at the amino acid range 2057-2107 |
| Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. |
| Protein Name | E1a-Binding Protein P400 Cag Repeat Protein 32 Domino Homolog Hdomino Trinucleotide Repeat-Containing Gene 12 Protein P400 Kda Swi2/Snf2-Related Protein |
| Database Links | Reactome: R-HSA-2559584 Reactome: R-HSA-2559586 Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E1a-Binding Protein P400 antibody Anti-Cag Repeat Protein 32 antibody Anti-Domino Homolog antibody Anti-Hdomino antibody Anti-Trinucleotide Repeat-Containing Gene 12 Protein antibody Anti-P400 Kda Swi2/Snf2-Related Protein antibody Anti-EP400 antibody Anti-CAGH32 antibody Anti-KIAA1498 antibody Anti-KIAA1818 antibody Anti-TNRC12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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