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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse PLN (Phospholamban) Sandwich ELISA Kit (STJE0011557)

  • 產(chǎn)品型號(hào)：STJE0011557
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Mouse PLN (Phospholamban) Sandwich ELISA Kit (STJE0011557)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PLN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Pln
Gene ID: 18821
Uniprot ID: PPLA_MOUSE
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in testis (at protein level).
Post Translational Modifications Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes. Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Palmitoylated by ZDHHC16, promoting formation of the homopentamer. In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis.
Function Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
Protein Name Cardiac Phospholamban
Plb
Database Links Reactome: R-MMU-5578775
Reactome: -MMU-936837
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Sarcoplasmic Reticulum Membrane
Mitochondrion Membrane
Membrane
Colocalizes With Hax1 At The Endoplasmic Reticulum
Colocalizes With Dmpk A The Sarcoplasmic Reticulum
Alternative ELISA Names Cardiac Phospholamban ELISA kit
Plb ELISA kit
Pln ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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