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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse PLA2G2D (Phospholipase A2, Group IID) Sandwich ELISA Kit Ready-To-Use (STJE0017915)

  • 產(chǎn)品型號(hào)：STJE0017915
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Mouse PLA2G2D (Phospholipase A2, Group IID) Sandwich ELISA Kit Ready-To-Use (STJE0017915)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 12.4pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This PLA2G2D Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Pla2g2d
Gene ID: 18782
Uniprot ID: PA2GD_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Highly expressed in secondary lymphoid tissues, spleen and lymph nodes. Expressed at a lesser extent in thymus. Expressed in CD4-positive, IL2RA/CD25-positive, FOXP3-positive Tregs (at protein level). Expressed in myeloid cell subsets resident in spleen and lymph nodes, ITGAX/CD11C-positive dendritic cells and macrophages (at protein level). Enriched in CD4-positive, ITGAM/CD11B-positive dendritic cell subset. Expressed in pulmonary ITGAX/CD11C-positive dendritic cell subset (at protein level).
Post Translational Modifications
Function Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins. During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response. May act in an autocrine and paracrine manner. Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance. May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane.
Protein Name Group Iid Secretory Phospholipase A2
Giid Spla2
Spla2-Iid
Pla2iid
Phosphatidylcholine 2-Acylhydrolase 2d
Secretory-Type Pla - Stroma-Associated Homolog
Database Links Reactome: R-MMU-1482788
Reactome: -MMU-1482801
Reactome: -MMU-1482839
Reactome: -MMU-1482922
Reactome: -MMU-1482925
Reactome: -MMU-1483166
Cellular Localisation Isoform 1: Secreted
Cell Membrane
Localizes To Cell Membrane Likely Through Binding To Heparan Sulfate Proteoglycans
Isoform 2: Cytoplasm
Alternative ELISA Names Group Iid Secretory Phospholipase A2 ELISA kit
Giid Spla2 ELISA kit
Spla2-Iid ELISA kit
Pla2iid ELISA kit
Phosphatidylcholine 2-Acylhydrolase 2d ELISA kit
Secretory-Type Pla - Stroma-Associated Homolog ELISA kit
Pla2g2d ELISA kit
Pla2a2 ELISA kit
Splash ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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