產(chǎn)品詳情
簡單介紹：
Anti-ENSA antibody (1-100) (STJ118111)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ENSA (1-100) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ENSA |
| Gene ID: | 2029 |
| Uniprot ID: | ENSA_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ENSA (NP_996929.1). |
| Immunogen Sequence: | MAGGLGCDVCYWFVEDTQEK EGILPERAEEAKLKAKYPSL GQKPGGSDFLMKRLQKGQKY FDSGDYNMAKAKMKNKQLPS AGPDKNLVTGDHIPTPQDLP |
| Tissue Specificity | Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. |
| Post Translational Modifications | Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA. |
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. |
| Protein Name | Alpha-Endosulfine Arpp-19e |
| Database Links | Reactome: R-HSA-2465910 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Alpha-Endosulfine antibody Anti-Arpp-19e antibody Anti-ENSA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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