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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ENPP2 antibody (564-863) (STJ23543)

  • 產(chǎn)品型號(hào)：STJ23543
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ENPP2 antibody (564-863) (STJ23543)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ENPP2 (564-863) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ENPP2
Gene ID: 5168
Uniprot ID: ENPP2_HUMAN
Immunogen Region: 564-863
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 564-863 of human ENPP2 (NP_001035181.1).
Immunogen Sequence: DLGCTCDDKVEPKNKLDELN KRLHTKGSTEERHLLYGRPA VLYRTRYDILYHTDFESGYS EIFLMPLWTSYTVSKQAEVS SVPDHLTSCVRPDVRVSPSF SQNCLAYKNDKQMSYGFLFP PYLSSSPEAKYDAFLVTNMV PMYPAFKRVWNYFQRVLVKK YASERNGVNVISGPIFDYDY DGLHDTEDKIKQYVEGSSIP VPTHYYSIITSCLDFTQPAD KCDGPLSVSSFILPHRPDN
Tissue Specificity Detected in blood plasma (at protein level). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.
Post Translational Modifications N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. The interdomain disulfide bond between Cys-414 and Cys-806 is essential for catalytic activity.
Function Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2
E-Npp 2
Autotaxin
Extracellular Lysophospholipase D
Lysopld
Database Links Reactome: R-HSA-199220
Cellular Localisation Secreted
Alternative Antibody Names Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 antibody
Anti-E-Npp 2 antibody
Anti-Autotaxin antibody
Anti-Extracellular Lysophospholipase D antibody
Anti-Lysopld antibody
Anti-ENPP2 antibody
Anti-ATX antibody
Anti-PDNP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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