產(chǎn)品詳情
簡(jiǎn)單介紹：
Anti-CD6 antibody (250-299 aa) (STJ92136)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-T-cell differentiation antigen CD6 (250-299 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD6 |
| Gene ID: | 923 |
| Uniprot ID: | CD6_HUMAN |
| Immunogen Region: | 250-299 aa |
| Specificity: | CD6 Polyclonal Antibody detects endogenous levels of CD6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CD6 at the amino acid range 250-299 |
| Post Translational Modifications | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated. |
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. |
| Protein Name | T-Cell Differentiation Antigen Cd6 T12 Tp120 Cd Antigen Cd6 Cleaved Into - Soluble Cd6 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Detected At The Immunological Synapse I E At The Contact Zone Between Antigen-Presenting Dendritic Cells And T-Cells Colocalizes With The Tcr/Cd3 Complex At The Immunological Synapse Soluble Cd6: Secreted The Origins Of The Secreted Form Are Not Clear But It Might Be Created By Proteolytic Shedding Of The Ectodomain |
| Alternative Antibody Names | Anti-T-Cell Differentiation Antigen Cd6 antibody Anti-T12 antibody Anti-Tp120 antibody Anti-Cd Antigen Cd6 Cleaved Into - Soluble Cd6 antibody Anti-CD6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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