產(chǎn)品詳情
簡單介紹：
Anti-CD5L antibody (20-347) (STJ27979)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CD5L (20-347) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD5L |
| Gene ID: | 922 |
| Uniprot ID: | CD5L_HUMAN |
| Immunogen Region: | 20-347 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-347 of human CD5L (NP_005885.1). |
| Immunogen Sequence: | SPSGVRLVGGLHRCEGRVEV EQKGQWGTVCDDGWDIKDVA VLCRELGCGAASGTPSGILY EPPAEKEQKVLIQSVSCTGT EDTLAQCEQEEVYDCSHDED AGASCENPESSFSPVPEGVR LADGPGHCKGRVEVKHQNQW YTVCQTGWSLRAAKVVCRQL GCGRAVLTQKRCNKHAYGRK PIWLSQMSCSGREATLQDCP SGPWGKNTCNHDEDTWVECE DPFDLRLVGGDNLCSGRLE |
| Tissue Specificity | Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues. |
| Post Translational Modifications | Not N-glycosylated. Probably not O-glycosylated. |
| Function | Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies. Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis. Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy. |
| Protein Name | Cd5 Antigen-Like Apoptosis Inhibitor Expressed By Macrophages Haim Ct-2 Igm-Associated Peptide Sp-Alpha |
| Cellular Localisation | Secreted Cytoplasm Secreted By Macrophages And Circulates In The Blood Transported In The Cytoplasm Via Cd36-Mediated Endocytosis |
| Alternative Antibody Names | Anti-Cd5 Antigen-Like antibody Anti-Apoptosis Inhibitor Expressed By Macrophages antibody Anti-Haim antibody Anti-Ct-2 antibody Anti-Igm-Associated Peptide antibody Anti-Sp-Alpha antibody Anti-CD5L antibody Anti-API6 antibody Anti-UNQ203 antibody Anti-PRO229 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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