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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EMR2 antibody (300-500) (STJ116490)

  • 產(chǎn)品型號：STJ116490
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-EMR2 antibody (300-500) (STJ116490)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EMR2 (300-500) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADGRE2
Gene ID: 30817
Uniprot ID: AGRE2_HUMAN
Immunogen Region: 300-500
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human EMR2 (NP_038475.2).
Immunogen Sequence: TIQSILQALDELLEAPGDLE TLPRLQQHCVASHLLDGLED VLRGLSKNLSNGLLNFSYPA GTELSLEVQKQVDRSVTLRQ NQAVMQLDWNQAQKSGDPGP SVVGLVSIPGMGKLLAEAPL VLEPEKQMLLHETHQGLLQD GSPILLSDVISAFLSNNDTQ NLSSPVTFTFSHRSVIPRQK VLCVFWEHGQNGCGHWATTG C
Tissue Specificity Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells.
Post Translational Modifications Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
Function Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.
Protein Name Adhesion G Protein-Coupled Receptor E2
Egf-Like Module Receptor 2
Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2
Cd Antigen Cd312
Database Links Reactome: R-HSA-373080
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Ruffle Membrane
Localized At The Leading Edge Of Migrating Cells
Alternative Antibody Names Anti-Adhesion G Protein-Coupled Receptor E2 antibody
Anti-Egf-Like Module Receptor 2 antibody
Anti-Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2 antibody
Anti-Cd Antigen Cd312 antibody
Anti-ADGRE2 antibody
Anti-EMR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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