產(chǎn)品詳情
簡單介紹：
Anti-EMG1 antibody (1-244) (STJ26667)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EMG1 (1-244) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EMG1 |
| Gene ID: | 10436 |
| Uniprot ID: | NEP1_HUMAN |
| Immunogen Region: | 1-244 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human EMG1 (NP_006322.4). |
| Immunogen Sequence: | MAAPSDGFKPRERSGGEQAQ DWDALPPKRPRLGAGNKIGG RRLIVVLEGASLETVKVGKT YELLNCDKHKSILLKNGRDP GEARPDITHQSLLMLMDSPL NRAGLLQVYIHTQKNVLIEV NPQTRIPRTFDRFCGLMVQL LHKLSVRAADGPQKLLKVIK NPVSDHFPVGCMKVGTSFSI PVVSDVRELVPSSDPIVFVV GAFAHGKVSVEYTEKMVSIS NYPLSAALTCAKLTTAFEE |
| Function | S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Ribosomal Rna Small Subunit Methyltransferase Nep1 18s Rrna Pseudouridine(1248-N1-Methyltransferase 18s Rrna Psi1248 Methyltransferase Nucleolar Protein Emg1 Homolog Protein C2f Ribosome Biogenesis Protein Nep1 |
| Database Links | Reactome: R-HSA-6790901 Reactome: R-HSA-6791226 |
| Cellular Localisation | Nucleus Nucleolus |
| Alternative Antibody Names | Anti-Ribosomal Rna Small Subunit Methyltransferase Nep1 antibody Anti-18s Rrna antibody Anti-Pseudouridine(1248-N1-Methyltransferase antibody Anti-18s Rrna Psi1248 Methyltransferase antibody Anti-Nucleolar Protein Emg1 Homolog antibody Anti-Protein C2f antibody Anti-Ribosome Biogenesis Protein Nep1 antibody Anti-EMG1 antibody Anti-C2F antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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