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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-Emerin antibody [4G5] (STJ16101736)

  • 產(chǎn)品型號(hào)：STJ16101736-1
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-Emerin antibody [4G5] (STJ16101736)
詳情介紹：
Host: Mouse
Applications: IHC-P/IHC-F
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Emerin is suitable for use in Immunohistochemistry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 4G5
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Lyophilized
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: EMD
Gene ID: 2010
Uniprot ID: EMD_HUMAN
Tissue Specificity Skeletal muscle, heart, colon, testis, ovary and pancreas.
Post Translational Modifications Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
Function Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.
Protein Name Emerin
Database Links Reactome: R-HSA-2980766
Reactome: R-HSA-2995383
Reactome: R-HSA-4419969
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013405
Reactome: R-HSA-9013408
Reactome: R-HSA-9013423
Reactome: R-HSA-9609523
Cellular Localisation Nucleus Inner Membrane
Single-Pass Membrane Protein
Nucleoplasmic Side
Nucleus Outer Membrane
Colocalized With Banf1 At The Central Region Of The Assembling Nuclear Rim
Near Spindle-Attachment Sites
The Accumulation Of Different Intermediates Of Prelamin-A/C (Non-Farnesylated Or Carboxymethylated Farnesylated Prelamin-A/C) In Fibroblasts Modify Its Localization In The Nucleus
Alternative Antibody Names Anti-Emerin antibody
Anti-EMD antibody
Anti-EDMD antibody
Anti-STA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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