產(chǎn)品詳情
簡單介紹：
Anti-EMD antibody (1-220) (STJ115860)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EMD (1-220) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EMD |
| Gene ID: | 2010 |
| Uniprot ID: | EMD_HUMAN |
| Immunogen Region: | 1-220 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human Emerin/Emerin/EMD (NP_000108.1). |
| Immunogen Sequence: | MDNYADLSDTELTTLLRRYN IPHGPVVGSTRRLYEKKIFE YETQRRRLSPPSSSAASSYS FSDLNSTRGDADMYDLPKKE DALLYQSKGYNDDYYEESYF TTRTYGEPESAGPSRAVRQS VTSFPDADAFHHQVHDDDLL SSSEEECKDRERPMYGRDSA YQSITHYRPVSASRSSLDLS YYPTSSSTSFMSSSSSSSSW LTRRAIRPENRAPGAGLGQD |
| Tissue Specificity | Skeletal muscle, heart, colon, testis, ovary and pancreas. |
| Post Translational Modifications | Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle. |
| Function | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. |
| Protein Name | Emerin |
| Database Links | Reactome: R-HSA-2980766 Reactome: R-HSA-2995383 Reactome: R-HSA-4419969 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013405 Reactome: R-HSA-9013408 Reactome: R-HSA-9013423 Reactome: R-HSA-9609523 |
| Cellular Localisation | Nucleus Inner Membrane Single-Pass Membrane Protein Nucleoplasmic Side Nucleus Outer Membrane Colocalized With Banf1 At The Central Region Of The Assembling Nuclear Rim Near Spindle-Attachment Sites The Accumulation Of Different Intermediates Of Prelamin-A/C (Non-Farnesylated Or Carboxymethylated Farnesylated Prelamin-A/C) In Fibroblasts Modify Its Localization In The Nucleus |
| Alternative Antibody Names | Anti-Emerin antibody Anti-EMD antibody Anti-EDMD antibody Anti-STA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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