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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ELK1 antibody [3H6D12/4H9C8/4H9F1] (STJ98017)

  • 產(chǎn)品型號(hào)：STJ98017
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ELK1 antibody [3H6D12/4H9C8/4H9F1] (STJ98017)
詳情介紹：
Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-ETS domain-containing protein Elk-1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 3H6D12/4H9C8/4H9F1
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ELK1
Gene ID: 2002
Uniprot ID: ELK1_HUMAN
Specificity: Elk1 Monoclonal Antibody detects endogenous levels of Elk1 protein.
Immunogen: Purified recombinant fragment of Elk1 expressed in E. Coli.
Post Translational Modifications Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1.
Function Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation.
Protein Name Ets Domain-Containing Protein Elk-1
Database Links Reactome: R-HSA-198753
Reactome: R-HSA-9031628
Reactome: R-HSA-9609690
Reactome: R-HSA-9634638
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Ets Domain-Containing Protein Elk-1 antibody
Anti-ELK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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