產(chǎn)品詳情
簡單介紹：
Anti-ELF3 antibody (N-Term) (STJA0005721)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ESE1 (N-Term) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 0.02% NaN3 |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 IHC ICC IP |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELF3 |
| Gene ID: | 1999 |
| Uniprot ID: | ELF3_HUMAN |
| Immunogen Region: | N-Term |
| Specificity: | Reacts with the N-terminal and C-terminal regions of human ESE1 protein |
| Immunogen: | Synthetic peptide corresponding to amino acids from the N-terminal and C-terminal regions of human ESE1 protein |
| Function | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGAAT. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. |
| Protein Name | Ets-Related Transcription Factor Elf-3 E74-Like Factor 3 Epithelial-Restricted With Serine Box Epithelium-Restricted Ets Protein Esx Epithelium-Specific Ets Transcription Factor 1 Ese-1 |
| Database Links | Reactome: R-HSA-1912408 |
| Cellular Localisation | Cytoplasm Nucleus Localizes To The Cytoplasm Where It Has Been Shown To Transform Mcf-12a Mammary Epithelial Cells Via A Novel Cytoplasmic Mechanism Also Transiently Expressed And Localized To The Nucleus Where It Induces Apoptosis In Non-Transformed Breast Epithelial Cells Mcf-10a And Mcf-12a Via A Transcription-Dependent Mechanism |
| Alternative Antibody Names | Anti-Ets-Related Transcription Factor Elf-3 antibody Anti-E74-Like Factor 3 antibody Anti-Epithelial-Restricted With Serine Box antibody Anti-Epithelium-Restricted Ets Protein Esx antibody Anti-Epithelium-Specific Ets Transcription Factor 1 antibody Anti-Ese-1 antibody Anti-ELF3 antibody Anti-ERT antibody Anti-ESX antibody Anti-JEN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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