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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EIF5A2 antibody (C-Term) (STJA0005725)

  • 產(chǎn)品型號(hào)：STJA0005725-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-EIF5A2 antibody (C-Term) (STJA0005725)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ElF5a2 (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 0.02% NaN3
Purification: Antigen Affinity Purified
Dilution Range: WB 1:500-1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF5A2
Gene ID: 56648
Uniprot ID: IF5A2_HUMAN
Immunogen Region: C-Term
Specificity: Reacts with the C-terminal region of the 17 kDa human, mouse and rat EIF5A2 protein.
Immunogen: Synthetic peptide corresponding to amino acids from the C-terminal region of human EIF5a2 protein.
Post Translational Modifications Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain and leads to the formation of a hypusine residue. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
Function Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step. Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.
Protein Name Eukaryotic Translation Initiation Factor 5a-2
Eif-5a-2
Eif-5a2
Eukaryotic Initiation Factor 5a Isoform 2
Database Links Reactome: R-HSA-204626
Cellular Localisation Cytoplasm
Nucleus
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Hypusine Modification Promotes The Nuclear Export And Cytoplasmic Localization And There Was A Dynamic Shift In The Localization From Predominantly Cytoplasmic To Primarily Nuclear Under Apoptotic Inducing Conditions
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 5a-2 antibody
Anti-Eif-5a-2 antibody
Anti-Eif-5a2 antibody
Anti-Eukaryotic Initiation Factor 5a Isoform 2 antibody
Anti-EIF5A2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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